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Venomic analysis of the poorly studied desert coral snake, Micrurus tschudii tschudii, supports the 3FTx/PLA2 dichotomy across Micrurus venoms
dc.creator | Sanz, Libia | |
dc.creator | Pla Ferrer, Davinia | |
dc.creator | Pérez, Alicia | |
dc.creator | Rodríguez, Yania | |
dc.creator | Zavaleta Martínez Vargas, Alfonso | |
dc.creator | Salas Arruz, María | |
dc.creator | Lomonte, Bruno | |
dc.creator | Calvete Chornet, Juan José | |
dc.date.accessioned | 2018-05-03T21:13:28Z | |
dc.date.available | 2018-05-03T21:13:28Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | http://www.mdpi.com/2072-6651/8/6/178 | |
dc.identifier.issn | 2072-6651 | |
dc.identifier.other | TOXIB7 | |
dc.identifier.uri | https://hdl.handle.net/10669/74607 | |
dc.description.abstract | The venom proteome of the poorly studied desert coral snake Micrurus tschudii tschudii was unveiled using a venomic approach, which identified ¥38 proteins belonging to only four snake venom protein families. The three-finger toxins (3FTxs) constitute, both in number of isoforms (~30) and total abundance (93.6% of the venom proteome), the major protein family of the desert coral snake venom. Phospholipases A2 (PLA2s; seven isoforms, 4.1% of the venom proteome), 1–3 Kunitz-type proteins (1.6%), and 1–2 L-amino acid oxidases (LAO, 0.7%) complete the toxin arsenal of M. t. tschudii. Our results add to the growing evidence that the occurrence of two divergent venom phenotypes, i.e., 3FTx- and PLA2-predominant venom proteomes, may constitute a general trend across the cladogenesis of Micrurus. The occurrence of a similar pattern of venom phenotypic variability among true sea snake (Hydrophiinae) venoms suggests that the 3FTx/PLA2 dichotomy may be widely distributed among Elapidae venoms. | es_ES |
dc.description.sponsorship | Ministerio de Economía y Competitividad/[BFU2013-42833-P]/Mineco/España | es_ES |
dc.language.iso | en_US | es_ES |
dc.rights | CC0 1.0 Universal | * |
dc.rights.uri | http://creativecommons.org/publicdomain/zero/1.0/ | * |
dc.source | Toxins, vol. 8 (6), 178. | es_ES |
dc.subject | Micrurus | es_ES |
dc.subject | Venom | es_ES |
dc.subject | Proteome | es_ES |
dc.subject | Venomics | es_ES |
dc.subject | Three-finger toxin | es_ES |
dc.subject | Snake venom phospholipase A 2 | es_ES |
dc.subject | Mass spectrometry | es_ES |
dc.subject | Micrurus tschudii tschudii | es_ES |
dc.title | Venomic analysis of the poorly studied desert coral snake, Micrurus tschudii tschudii, supports the 3FTx/PLA2 dichotomy across Micrurus venoms | es_ES |
dc.type | artículo original | |
dc.identifier.doi | 10.3390/toxins8060178 | |
dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP) | es_ES |
dc.identifier.pmid | PMC4926144 | |
dc.identifier.pmid | 27338473 |
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Microbiología [1171]