Show simple item record

dc.creatorChevrette, Marc G.
dc.creatorCarlson, Caitlin M.
dc.creatorOrtega Dominguez, Humberto Enrique
dc.creatorThomas, Christopher S.
dc.creatorAnaniev, Gene E.
dc.creatorBarns, Kenneth J.
dc.creatorBook, Adam J.
dc.creatorCagnazzo, Julian
dc.creatorCarlos Shanley, Camila
dc.creatorFlanigan, Will
dc.creatorGrubbs, Kirk J.
dc.creatorHorn, Heidi A.
dc.creatorHoffmann, F. Michael
dc.creatorKlassen, Jonathan L.
dc.creatorKnack, Jennifer J.
dc.creatorLewin, Gina R.
dc.creatorMcDonald, Bradon R.
dc.creatorMuller, Laura K.
dc.creatorMelo, Weilan Gomes da Paixão
dc.creatorPinto Tomás, Adrián A.
dc.creatorSchmitz, Amber Marie
dc.creatorWendt-Pienkowski, Evelyn
dc.creatorWildman, Scott
dc.creatorZhao, Miao
dc.creatorZhang, Fan
dc.creatorBugni, Tim S.
dc.creatorAndes, David R.
dc.creatorPupo, Monica Tallarico
dc.creatorCurrie, Cameron Robert
dc.date.accessioned2019-11-21T16:41:48Z
dc.date.available2019-11-21T16:41:48Z
dc.date.issued2019
dc.identifier.citationhttps://www.nature.com/articles/s41467-019-08438-0#Abs1es_ES
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/10669/79896
dc.description.abstractAntimicrobial resistance is a global health crisis and few novel antimicrobials have been discovered in recent decades. Natural products, particularly from Streptomyces, are the source of most antimicrobials, yet discovery campaigns focusing on Streptomyces from the soil largely rediscover known compounds. Investigation of understudied and symbiotic sources has seen some success, yet no studies have systematically explored microbiomes for antimicrobials. Here we assess the distinct evolutionary lineages of Streptomyces from insect microbiomes as a source of new antimicrobials through large-scale isolations, bioactivity assays, genomics, metabolomics, and in vivo infection models. Insect-associated Streptomyces inhibit antimicrobial-resistant pathogens more than soil Streptomyces. Genomics and metabolomics reveal their diverse biosynthetic capabilities. Further, we describe cyphomycin, a new molecule active against multidrug resistant fungal pathogens. The evolutionary trajectories of Streptomyces from the insect microbiome influence their biosynthetic potential and ability to inhibit resistant pathogens, supporting the promise of this source in augmenting future antimicrobial discovery.es_ES
dc.description.sponsorshipNational Institutes of Health/[NIH U19 Al109673]/NIH/Estados Unidoses_ES
dc.description.sponsorshipNational Institutes of Health/[NIH U19 TW009872]/NIH/Estados Unidoses_ES
dc.description.sponsorshipUniversidad de Costa Rica/[801-B0-538]/UCR/Costa Ricaes_ES
dc.description.sponsorshipUniversidad de Costa Rica/[810-B3-185]/UCR/Costa Ricaes_ES
dc.description.sponsorshipThe São Paulo Research Foundation/[#2013/50954-0]/FAPESP/Brasiles_ES
dc.description.sponsorshipThe São Paulo Research Foundation/[#2014/14095-6]/FAPESP/Brasiles_ES
dc.description.sponsorshipNational Research Service Award/[T32 GM008505]/NIDCD/Estados Unidoses_ES
dc.description.sponsorshipNational Science Foundation/[MCB-0702025]/NSF/Estados Unidoses_ES
dc.language.isoen_USes_ES
dc.sourceNature Communications, vol.10(516), pp.1-11es_ES
dc.subjectStreptomyceses_ES
dc.subjectBacteriaes_ES
dc.subjectInsect microbiomees_ES
dc.titleThe antimicrobial potential of Streptomyces from insect microbiomeses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.date.updated2019-11-19T20:47:14Z
dc.identifier.doi10.1038/s41467-019-08438-0
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Estructuras Microscópicas (CIEMIC)es_ES
dc.identifier.codproyecto801-B0-538
dc.identifier.codproyecto810-B3-185


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record