Revista Médica de la UCR 6(1)

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  • Ítem
    SÍNDROME HEPATOPULMONAR
    (2013-03-04 00:00:00) Álvarez Arguedas, Karina
    Hepatopulmonary syndrome (HPS) is an underdiagnosed syndrome that is defined as a clinical triad of advanced liver disease, arterial deoxygenation and intrapulmonary vascular dilatation. It is a rare complication of liver disease of varied etiologies and indicates a poor prognosis. Many theories have been put forward to throw light over its pathogenesis. The major clinical manifestations are arterial hypoxemia, clubbed fingers and spider naevi. Orthodeoxia and platypnea are usual clinical features. A simple non invasive  method to screen HPS is desirable. Contrast enhanced 2D Echo cardiography is the preferred  screening test. No effective medical treatment has been found. Although liver transplant seems feasible to reverse, at least partially, this situation. Long-term oxygen therapy pre and post liver transplant might offer a new therapeutic approach to improve liver function in patients with cirrhosis with hypoxemia.
  • Ítem
    NEUMONÍA BACTERIANA CON DESARROLLO DE ABSCESOS PULMONARES SECUNDARIOS A INFECCIÓN CAUSADA POR STREPTOCOCCUS INTERMEDIUS PROVENIENTE DE ABSCESO DENTAL
    (2013-03-04 00:00:00) Álvarez Herrera, Leonardo
    A case of a 29 years old male patient is presented; having asthma and psoriasis as his only personal pathological antecedents he developed pneumonia with multiple pulmonary bilateral abscess caused by the bacteria Streptococcus intermedius coming from a dental abscess. The patient required hospital admission for 17 days and received endovenous treatment with Ampilicin/Sulbactam in a dose of 1,5 g each 6 hours for 2 weeks, showing clinical recovery and being discharged of the health center with the same antibiotic treatment for one more month administered via oral.
  • Ítem
    ESTIMACIÓN DE LA RESISTENCIA Y SENSIBILIDAD ANTIMICROBIANA EN LAS INFECCIONES DEL TRACTO URINARIO EN EL PRIMER NIVEL DE ATENCIÓN DEL ÁREA DE SALUD DE MONTES DE OCA, NÚCLEO VARGAS ARAYA, PERIODO ENERO 2009 A DICIEMBRE 2010
    (2013-03-04 00:00:00) Ajú Marchena, Greddy
    Urinary tract infections are frequent cause of consultation in primay care, so that successful treatment involves a decrease in morbidity and sometimes mortality from this disease. The primary care program Programa de Atención Integral de Salud convenio UCR-CCSS (PAIS) is not an exception as there are considerable number of visits for this condition and the female is most affected. We obtained 88 cases of urinary tract infection whit positive urine cultures from January 2009 to December 2010, six were men and 82 women, the average age was 52.4 years with a standard deviation 21.74 years. Escherichia coli corresponds to 77.3% of the cases, with a resistance of 47.1% to Trimethoprim-sulfamethoxazole, Nitrofurantoin is still a good therapeutic option for empirical treatment of UTIs.
  • Ítem
    PRECLINICAL VALIDATION STUDY OF THE ANTICANCER TRADITIONAL USE OF UNCARIA TOMENTOSA (CAT´S CLAW)
    (2013-03-04 14:10:34) Díaz Oreiro, Cecilia; Vargas Arroyo, Mariángela
    Uncaria tomentosa has been widely used in several countries as an anticancer remedy, but due to its pharmacological effects this plant has been extensively harvested and faces extinction.     Regardless of its traditional anti-tumoral use, root bark water extract was the lesser active extract. Hydroalcoholic preparation of the root bark showed LD50 ranging from 150 to 500 μg/mL and leaf extracts (water and hydroalcoholic) showed LD50 as low as 180.1μg/mL.  Selectivity index showed that except for astrocytoma and leukemia, all tumor cells were 2-8 times more sensitive to the extracts than to non tumor cells.  Oxindole pentacyclic alkaloids (mitraphylline, isomitraphylline, uncarine C and uncarine E) are present in the extracts and they probably play a role in the cytotoxic effect on tumor cell lines.  Our study suggets that Uncaria tomentosa roots could be replaced by the leaves in order to obtain good pharmacological results, protecting the plant from extinction.