Characterization and phylogenetic relationships of strains of Dengue type 1 virus from Costa Rica

Abstract

Phylogenetic analysis of the envelope gene sequence (E) of three isolated Dengue virus type 1 (DEN- 1) sequences from the Costa Rican 1993 epidemic was performed. All the strains fell into genotype V. Genotype V has grouped all the strains isolated from America, three strains from Africa and two strains from Asia. Costa Rican strains are closely related to the strain from Angola and to the Brazil 1990 strain. Costa Rican strains are able to cause DHF but with low clinical disease severity and low incidence maybe because of low virulence.Tres aislamientos del gen de la envoltura (E) de Dengue tipo 1 del período epidémico de 1993 en Costa Rica se analizaron filogenéticamente. Todas las cepas pertenecen al genotipo V. El genotipo V ha agrupado todos los aislamientos de América, tres cepas de África y dos cepas de Asia. Los aislamientos costarricenses están cercanamente relacionados a la cepa de Angola y al aislamiento brasileño de 1990. Las cepas costarricenses son capaces de causar Fiebre de Dengue Hemorrágico pero con baja severidad clínica y baja incidencia quizá debido a una baja virulencia.