Mostrar el registro sencillo del ítem

dc.creatorBrenes García, Oscar Gerardo
dc.date.accessioned2023-03-15T13:44:08Z
dc.date.available2023-03-15T13:44:08Z
dc.date.issued2022-03-30
dc.identifier.citationhttps://link.springer.com/article/10.1007/s12551-022-00942-wes_ES
dc.identifier.issn1867-2469
dc.identifier.issn1867-2450
dc.identifier.urihttps://hdl.handle.net/10669/88321
dc.description.abstractEpilepsy is a neurological disorder characterized by a hyperexcitable state in neurons from different brain regions. Much is unknown about epilepsy and seizures development, depicting a growing field of research. Animal models have provided important clues about the underlying mechanisms of seizure-generating neuronal circuits. Mammalian complexity still makes it difficult to define some principles of nervous system function, and non-mammalian models have played pivotal roles depending on the research question at hand. Mollusks and the Helix land snail have been used to study epileptic-like behavior in neurons. Neurons from these organisms confer advantages as single-cell identification, isolation, and culture, either as single cells or as physiological relevant monosynaptic or polysynaptic circuits, together with amenability to different protocols and treatments. This review’s purpose consists in presenting relevant papers in order to gain a better understanding of Helix neurons, their characteristics, uses, and capabilities for studying the fundamental mechanisms of epileptic disorders and their treatment, to facilitate their more expansive use in epilepsy research.es_ES
dc.language.isoenges_ES
dc.sourceBiophysical Reviews, Vol.14, pp. 553-568es_ES
dc.subjectEpilepsyes_ES
dc.subjectAnimal modelses_ES
dc.subjectHelix pomatiaes_ES
dc.subjectHelix aspersaes_ES
dc.subjectDrug screeninges_ES
dc.subjectIon channelses_ES
dc.subjectSynaptic vesicleses_ES
dc.titleInvertebrate neurons as a simple model to study the hyperexcitable state of epileptic disorders in single cells, monosynaptic connections, and polysynaptic circuitses_ES
dc.typeartículo originales_ES
dc.identifier.doi10.1007/s12551-022-00942-w
dc.description.procedenceUCR::Vicerrectoría de Docencia::Salud::Facultad de Medicina::Escuela de Medicinaes_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Centro de Investigación en Neurociencias (CIN)es_ES
dc.identifier.codproyecto422-C0-608


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem