Partial efficacy of a Brazilian coralsnake antivenom and Varespladib to neutralize distinct toxic effects induced by a sublethal Micrurus dumerilii carinicauda envenoming in rats
Fecha
2022
Tipo
artículo original
Autores
Silva Carvalho, Rosimeire
Gaspar, Matheus Z.
Quadros, Luiz H. B.
Lobo, Luís G. G.
Giuffrida, Rogério
Santarém, Cecília L.
Silva, Elisangela O.
Gerez, Juliana Rubira
Silva, Nelson J.
Hyslop, Stephen
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Resumen
In this work, we reported the efficacy of a combination of Brazilian therapeutic coralsnake antivenom (CAV) and varespladib (phospholipase A2 inhibitor – VPL) in partially neutralizing selected toxic effects of Micrurus dumerilii carinicauda coralsnake venom in rats. Venom caused local myonecrosis and systemic neurotoxicity, nephrotoxicity, and hepatotoxicity within 2 h of injection. CAV and VPL administered separately failed to prevent most of these alterations. However, a combination of CAV plus VPL offered variable protection against venom-induced coagulation disturbances, leukocytosis, and renal-hepatic morphological alterations
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Palabras clave
Micrurus, varespladib, SUSTANCIA PELIGROSA, Snake venom