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Partial efficacy of a Brazilian coralsnake antivenom and Varespladib to neutralize distinct toxic effects induced by a sublethal Micrurus dumerilii carinicauda envenoming in rats

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dc.creatorSilva Carvalho, Rosimeire
dc.creatorGaspar, Matheus Z.
dc.creatorQuadros, Luiz H. B.
dc.creatorLobo, Luís G. G.
dc.creatorGiuffrida, Rogério
dc.creatorSantarém, Cecília L.
dc.creatorSilva, Elisangela O.
dc.creatorGerez, Juliana Rubira
dc.creatorSilva, Nelson J.
dc.creatorHyslop, Stephen
dc.creatorLomonte, Bruno
dc.creatorFloriano, Rafael Stuani
dc.date.accessioned2023-01-05T18:54:03Z
dc.date.available2023-01-05T18:54:03Z
dc.date.issued2022
dc.description.abstractIn this work, we reported the efficacy of a combination of Brazilian therapeutic coralsnake antivenom (CAV) and varespladib (phospholipase A2 inhibitor – VPL) in partially neutralizing selected toxic effects of Micrurus dumerilii carinicauda coralsnake venom in rats. Venom caused local myonecrosis and systemic neurotoxicity, nephrotoxicity, and hepatotoxicity within 2 h of injection. CAV and VPL administered separately failed to prevent most of these alterations. However, a combination of CAV plus VPL offered variable protection against venom-induced coagulation disturbances, leukocytosis, and renal-hepatic morphological alterationses_ES
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)es_ES
dc.identifier.citationhttps://www.sciencedirect.com/science/article/abs/pii/S0041010122001167?via%3Dihubes_ES
dc.identifier.doidoi.org/10.1016/j.toxicon.2022.04.014
dc.identifier.issn0041-0101
dc.identifier.urihttps://hdl.handle.net/10669/88017
dc.language.isoenges_ES
dc.rightsacceso embargado
dc.sourceToxicon 213 (2022), 99-104es_ES
dc.subjectMicruruses_ES
dc.subjectvarespladibes_ES
dc.subjectSUSTANCIA PELIGROSAes_ES
dc.subjectSnake venomes_ES
dc.titlePartial efficacy of a Brazilian coralsnake antivenom and Varespladib to neutralize distinct toxic effects induced by a sublethal Micrurus dumerilii carinicauda envenoming in ratses_ES
dc.typeartículo originales_ES

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