Mechanical ventilator development during COVID-19 crisis: Preclinical data analysis from porcine bio-model

Fecha

2024-10-31

Tipo

artículo original

Autores

Conejo Rodríguez, Elian
Araya Jiménez, Carlos Andrés
Calderón Obaldía, Eduardo
García Vindas, José Ralph

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Resumen

This paper describes a mechanical ventilator prototype with preclinical test performed on 10 bioporcine models, where tests were performed for eight hours for each individuals, giving the respective life support on different scenarios inducing stress and evaluating that each subject physiological parameters remain and return swiftly to the normal values. The results have shown the capabilities to maintain physiological parameters for each subject under test and present also the capability of monitoring the pulmonary parameter, compliance (C), computed from the pressure-volume hysteresis loop measured by the prototype, so that this is the unique proposed prototype to present this capability at this extended subject samples. The ventilator prototype was designed following the Medicine & Healthcare products Regulatory Agency (MHRA) from United Kingdom (UK), that was the first guidelines for manufactured ventilator system in the pandemic of COVID-19 emergency. Finally the components used in the mechanical ventilator comes from different industrial applications, that its performances were tested for years and its supply were no affected by the surge of the acquisition of critical electro-mechanical components used by the commercial ventilator factories under pandemic situation as COVID-19 pandemic.

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Palabras clave

compliance, COVID-19, mechanical ventilator, pressure-volume hysteresis loop, porcine bio-model, preclinical data