507. Association of NRXN3 deletion with schizophrenia and bipolar disorder

Shavit, Ayal; Gonzalez, Jessica; Chavez, Maricela; Rodriguez, Marco A.; Camarillo, Cynthia; Ramírez, Mercedez Ellis; Zavala, Juan Manuel; Contreras Rojas, Javier; Raventós Vorst, Henriette; Flores, Deborah Lynne; Jerez Magaña, Álvaro Antonio; Ontiveros Sánchez de la Barquera, José Alfonso; Nicolini Sánchez, José Humberto; Escamilla, Michael A.; Gonzalez, Suzanne

507. Association of NRXN3 deletion with schizophrenia and bipolar disorder

Fecha

2017-05-17

Autores

Shavit, Ayal

Gonzalez, Jessica

Chavez, Maricela

Rodriguez, Marco A.

Camarillo, Cynthia

Ramírez, Mercedez Ellis

Zavala, Juan Manuel

Contreras Rojas, Javier

Raventós Vorst, Henriette

Flores, Deborah Lynne

Resumen

Schizophrenia (SZ) and bipolar disorder (BD) are the most severe neuropsychiatric disorders affecting 1.2% and 4.4% of Americans, respectively. Certain genes coding for proteins involved in pre-synaptic machinery are thought to play a role in the pathophysiology of the disorder. Deficits in the calcium channel regulator gene NRXN3 have been associated with behaviors of impulsivity and alcohol and drug dependence, which are traits characteristic of BD and SZ.