Cirugía citorreductora y quimioterapia intraperitoneal hipertérmica para manejo de carcinomatosis peritoneal en paciente con cáncer colorrectal
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Obando Murillo, Stephanie
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Abstract
Costa Rica es un país dinámico, a la vanguardia de los avances en el tratamiento del cáncer colorrectal. En este trabajo, se propone que, si se realiza una revisión bibliográfica acerca de la cirugía citorreductora con quimioterapia hipertérmica intraperitoneal para el paciente con carcinomatosis peritoneal secundaria a cáncer colorrectal, se podrán establecer los beneficios de un protocolo de manejo perioperatorio que se podría implementar en los centros de salud del sistema social costarricense.
El peritoneo es el tercer sitio más frecuente de metástasis en cáncer de colon y el cuarto en el cáncer rectal. Se suele asociar a una menor sobrevida comparado con otros sitios de metástasis. Una oportunidad para extender la supervivencia en CCRmp comienza controlando la carga de enfermedad peritoneal y reduciendo o retrasando sus complicaciones. Dentro de las modalidades terapéuticas existe la propuesta de realizar cirugía citorreductora en combinación con quimioterapia intraperitoneal hipertérmica, siempre y cuando se reúnan las condiciones adecuadas y, de esta manera, favorecer no solo la sobrevida, sino también la calidad de vida del paciente oncológico con cáncer colorrectal.
Aunque se puede lograr una supervivencia a largo plazo en un pequeño número de pacientes mediante la citorreducción quirúrgica agresiva seguida de quimioterapia intraperitoneal hipertérmica, siguen existiendo pruebas insuficientes.
Costa Rica is a dynamic country, at the forefront of treatment in colorectal cancer. It is proposed that, if an extensive literature review is carried out on cytoreductive surgery with intraperitoneal hyperthermic chemotherapy for the patient with peritoneal carcinomatosis secondary to colorectal cancer, the benefits of a perioperative management protocol that could be implemented in health centers can be established for the Costa Rican social health care system. The peritoneum is the third most frequent site of metastasis in colon cancer, and the fourth in rectal cancer. It is usually associated with a lower survival compared to other sites of metastasis. An opportunity to extend survival in mpCCR begins by controlling the burden of peritoneal disease and reducing or delaying its complications. The optimal management of patients with peritoneal carcinomatosis without distant disease after rigorous diagnostic evaluation is controversial. Although long-term survival can be achieved in a small number of patients by aggressive surgical debulking followed by hyperthermic intraperitoneal chemotherapy, insufficient evidence remains.
Costa Rica is a dynamic country, at the forefront of treatment in colorectal cancer. It is proposed that, if an extensive literature review is carried out on cytoreductive surgery with intraperitoneal hyperthermic chemotherapy for the patient with peritoneal carcinomatosis secondary to colorectal cancer, the benefits of a perioperative management protocol that could be implemented in health centers can be established for the Costa Rican social health care system. The peritoneum is the third most frequent site of metastasis in colon cancer, and the fourth in rectal cancer. It is usually associated with a lower survival compared to other sites of metastasis. An opportunity to extend survival in mpCCR begins by controlling the burden of peritoneal disease and reducing or delaying its complications. The optimal management of patients with peritoneal carcinomatosis without distant disease after rigorous diagnostic evaluation is controversial. Although long-term survival can be achieved in a small number of patients by aggressive surgical debulking followed by hyperthermic intraperitoneal chemotherapy, insufficient evidence remains.
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Quimioterapia intraperitoneal hipertérmica (HIPEC), Cirugía citorreductora, Cáncer colorrectal, Carcinomatosis peritoneal