Acute Hepatic Response to Diet Modification and Exercise-induced Endotoxemia during a Laboratory-based Duathlon
dc.creator | Moncada Jiménez, José | |
dc.creator | Plaisance, Eric Paul | |
dc.creator | Araya Ramírez, Felipe | |
dc.creator | Taylor, James K. | |
dc.creator | Ratcliff, Lance | |
dc.creator | Mestek, Michael L. | |
dc.creator | Grandjean, Peter Walter | |
dc.creator | Aragón Vargas, Luis Fernando | |
dc.date.accessioned | 2018-06-19T16:32:40Z | |
dc.date.available | 2018-06-19T16:32:40Z | |
dc.date.issued | 2010-01 | |
dc.description.abstract | The purpose of the study was to compare the acute hepatic response to diet modification and exercise-induced endotoxemia, and to determine if associations exist between liver damage markers, body core temperature, and IL-6 responses to a laboratory-based duathlon. Eleven moderately-trained healthy males followed a low-carbohydrate (CHO) and a high CHO diet to change their glycogen stores two-days before completing a duathlon. Blood samples were obtained at rest, immediately after and 1- and 2-h following the duathlon for determination of endotoxin-lipopolysaccharide binding protein (LPS-LBP) complex, IL-6, and liver integrity markers AST, ALT, and AST/ALT ratio. Hydration status and body core temperature were assessed at rest, during, and after the duathlon. Athletes were more dehydrated and had higher AST/ALT ratios in the lowcompared to the high-CHO diet trial regardless of the measurement time (p<0.05). IL-6 increased from resting to immediately after, 1- and 2-h following duathlon regardless of the diet (p<0.05). A higher LPS-LBP complex concentration was observed from rest to immediately after the duathlon. No significant correlations were found between LPS-LBP complex levels and body core temperature. In conclusion, athletes on a low-CHO diet showed higher hepatic structural damage and finished more dehydrated compared to athletes on a high-CHO diet. Body core temperature and LPS-LBP complex levels were unrelated beyond the increase in body core temperature explained by exercise. No significant associations were found between body core temperature, IL-6 and LPS-LBP complex concentrations. | es_ES |
dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Sociales::Centro de Investigación en Ciencias del Movimiento Humano (CIMOHU) | es_ES |
dc.identifier.citation | https://www.ingentaconnect.com/content/doaj/0860021x/2010/00000027/00000002/art00007 | |
dc.identifier.issn | 0860-021X | |
dc.identifier.uri | https://hdl.handle.net/10669/74945 | |
dc.language.iso | en_US | es_ES |
dc.rights | acceso abierto | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.source | Biology of Sport, Vol 27(2), pp. 111-118 | es_ES |
dc.subject | human | es_ES |
dc.subject | cytokines | es_ES |
dc.subject | lipopolysaccharide | es_ES |
dc.subject | infammation | es_ES |
dc.subject | exercise | es_ES |
dc.subject | humano | es_ES |
dc.subject | citocinas | es_ES |
dc.subject | lipopolisacárido | es_ES |
dc.subject | ejercicio | es_ES |
dc.subject | inflamación | es_ES |
dc.subject | 796.607 8 Ciclismo y actividades relacionadas | es_ES |
dc.title | Acute Hepatic Response to Diet Modification and Exercise-induced Endotoxemia during a Laboratory-based Duathlon | es_ES |
dc.type | artículo original |
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