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Homogenates of skeletal muscle injected with snake venom inhibit myogenic differentiation in cell culture
(2013-02)Introduction: Viperid snakebite envenomings are characterized by muscle necrosis and a deficient regenerative response. Methods: Homogenates from gastrocnemius muscles of mice injected with the venom of the snake Bothrops ... -
Homozygous Mutation in GPT2 Associated with Nonsyndromic Intellectual Disability in a Consanguineous Family from Costa Rica
(2016)Intellectual disability is a highly heterogeneous disease that affects the central nervous system and impairs patients’ ability to function independently. Despite multiples genes involved in the etiology of disease, most ... -
Hormone replacement therapy reduces lipid oxidation directly at the arterial wall: A possible link to estrogens’ cardioprotective effect through atherosclerosis prevention
(2018)Background: The first step in atherosclerosis formation is the ingurgitation of an oxidized low‑density lipid (LDL) molecule by a macrophage which then turns into a foam cell within the vascular wall and initiates a ... -
Horse IgG isotypes and cross-neutralization of two snake antivenoms produced in Brazil and Costa Rica
(2000-05)Horse IgG isotypes and cross-neutralization of two snake antivenoms produced in Brazil and Costa Rica. Toxicon 000–000. This work compared the specificity, ELISA titers and IgG subclass content of the polyvalent antivenom ... -
Horse immunization with short-chain consensus α-neurotoxin generates antibodies against broad spectrum of elapid venomous species
(2019)Antivenoms are fundamental in the therapy for snakebites. In elapid venoms, there are toxins, e.g. short-chain α-neurotoxins, which are quite abundant, highly toxic, and consequently play a major role in envenomation ... -
Hospital disinfectant efficacy testing: Experimental evidence towards the requirement of common international regulatory framework, the case of Costa Rica
(2023)Background: Costa Rica, as many developing countries around the world, lacks a specific regulatory framework for hospital disinfectant efficacy testing. The aim of this study is to evaluate the efficacy of disinfectant ... -
Host response to Bothrops asper snake venom: analysis of edema formation, inflammatory cells, and cytokine release in a mouse model
(1993)As part of tle characterization of the host reactivity to the venom of Bothrops asper, we investigated the inflammatory responses in the mouse footpad model. The subcutaneously iniected venom induced a rapid increase of ... -
Host-Feeding Patterns of the Mosquito Assemblage at Lomas Barbudal Biological Reserve, Guanacaste, Costa Rica
(2021-07)Mosquito-borne pathogens have spread throughout tropical regions of the Western Hemisphere causing increased burden of disease in the region. Outbreaks of dengue fever, yellow fever, chikungunya, West Nile, and Zika have ... -
How harmful is diarrhoea?
(1986-04)Apart from the physical suffering and deaths that they cause at the individual and family level, diarrhoeal diseases also play a negative role in national development -
HRMS characterization, antioxidant and cytotoxic activities of polyphenols in Malus domestica cultivars from Costa Rica
(2021)There is increasing interest in research into fruits as sources of secondary metabolites because of their potential bioactivities. In this study, the phenolic profiles of Malus domestica Anna and Jonagold cultivars from ... -
HRT decreases DNA and lipid oxidation in postmenopausal women.
(2013)Background: Postmenopausal women have increased oxidative stress and decreased antioxidant status. Estrogen has great antioxidant capacity both in vitro and in vivo. Few authors have studied the effect that hormone replacement ... -
Human Cytomegalovirus Fcγ Binding Proteins gp34 and gp68 Antagonize Fcγ Receptors I, II and III
(2014-05-15)Human cytomegalovirus (HCMV) establishes lifelong infection with recurrent episodes of virus production and shedding despite the presence of adaptive immunological memory responses including HCMV immune immunoglobulin G ... -
Human heterophilic antibodies against equine immunoglobulins: assessment of their role in the early adverse reactions to antivenom administration
(2008)The presence of human heterophilic antibodies against horse immunoglobulins (HHA-HI) was determined by ELISA in sera from healthy volunteers and from patients who received equine antivenom for therapy of snake bite ... -
Human Papiloma Virus in lung cancer tissue. Experience at the Calderon Guardia Hopsital
(2012-11-20)Background: The epidemiology of lung cancer, a major cause of morbidity throughout the world and the leading cause of mortality among adult men and women, has changed substantially in the past few years. Some of these ... -
Hybrid mathematical modeling decodes the complexity of sphingolipid pathway to predict chemosensitivity
(2017)Sphingolipid (SL) signaling pathway is a complex biological system able to integrate different types of cellular stress signals related to induction of cell death pathways with special interest in cancer. This makes of ... -
Hydrocarbon Degrading Microflora in a Tropical fuel-Contaminated Aquifer: Assessing the Feasibility of PAH Bioremediation
(2012-01)An aquifer located within a petroleum processing plant in Moín, Costa Rica, suffers hydrocarbon pollution. This study aimed to determine the ability of indigenous microorganisms from this site to degrade polycyclic ... -
Hydrology Affects Environmental and Spatial Structuring of Microalgal Metacommunities in Tropical Pacific Coast Wetlands
(2016-02-22)The alternating climate between wet and dry periods has important effects on the hydrology and therefore on niche-based processes of water bodies in tropical areas. Additionally, assemblages of microorganism can show spatial ... -
Hyperalgesia induced by Asp49 and Lys49 phospholipases A2 from Bothrops asper snake venom: pharmacological mediation and molecular determinants
(2003-05)The ability of Lys49 and Asp49 phospholipases A2 (PLA2), from Bothrops asper snake venom, to cause hyperalgesia was investigated in rats, using the paw pressure test. Intraplantar injection of both toxins (5–20 μg/paw) ...