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Caracterización proteómica y toxicológica del veneno de Crotalus pifanorum (viperidae) y evaluación de su uso como inmunógeno sobre la respuesta por anticuerpos contra co-inmunógenos y venenos de otros crótalos americanos
(2019)
En Costa Rica se produce un antiveneno poliespecífico (PoliVal-ICP) usando como inmunógenos los venenos de las serpientes Bothrops asper, Crotalus simus y Lachesis stenophrys. Este antiveneno es capaz de neutralizar a la ...
Stability of equine IgG antivenoms obtained by caprylic acid precipitation: Towards a liquid formulation stable at tropical room temperature
(2009-05)
Liquid formulations of antivenom require a cold chain for their distribution and storage, especially in tropical countries characterized by high temperature and humidity (climatic zone IV). Since cold chain is often deficient ...
Anticomplementary activity of equine whole IgG antivenoms: comparison of three fractionation protocols
(2005-01)
Early adverse reactions occur in a number of patients treated with heterologous antivenoms and have been associated with anticomplementary activity (ACA). In order to reduce the ACA of equine whole IgG antivenoms produced ...
Heterologous hyperimmune polyclonal antibodies against SARS-COV-2: A broad coverage, affordable, and scalable potential immunotherapy for Covid-19
(2021-09)
The emergence and dissemination of the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) and the resulting COVID-19 pandemic triggered a global public health crisis.
Although several SARS-CoV-2 vaccines have ...
Assessing endotoxins in equine-derived snake antivenoms: Comparison of the USP pyrogen test and the Limulus Amoebocyte Lysate assay (LAL)
(2015-08-29)
Snake antivenoms are parenterally administered; therefore, endotoxin content must be strictly controlled. Following international indications to calculate endotoxin limits, it was determined that
antivenom doses between ...
Comparación entre inmunización pasiva e inmunización activa como procedimiento para controlar los envenenamientos producidos por la serpiente Bothrops asper (terciopelo) en un modelo canino
(2020)
Los accidentes ofídicos en animales domésticos son un problema importante para la garantía del bienestar animal en Costa Rica. En este trabajo se comparó la inmunización pasiva por administración de antivenenos con la ...
Inhibition by CaNa2EDTA of local tissue damage induced by Bothrops asper (terciopelo) venom: Application in horse immunization for antivenom production
(1998-03-26)
The ability of the chelating agent CaNa2EDTA to inhibit local tissue damage induced by Bothrops asper venom was studied in mice and in horses used for polyvalent (Crotalinae) antivenom production. CaNa2EDTA was devoid of ...
Preclinical evaluation of the efficacy of antivenoms for snakebite envenoming: State-of-the-art and challenges ahead
(2017-05)
Animal-derived antivenoms constitute the mainstay in the therapy of snakebite envenoming. The efficacy of antivenoms to neutralize toxicity of medically-relevant snake venoms has to be demonstrated through meticulous ...
Comparison of the adjuvant activity of aluminum hydroxide and calcium phosphate on the antibody response towards Bothrops asper snake venom
(2014)
The adjuvanticity of aluminum hydroxide and calcium phosphate on the antibody response in
mice towards the venom of the snake Bothrops asper was studied. It was found that, in vitro,
most of the venom proteins are similarly ...
Pathogenic mechanisms underlying adverse reactions induced by intravenous administration of snake antivenoms
(2013-12-15)
Snake antivenoms are formulations of immunoglobulins, or immunoglobulin fragments, purified from the plasma of animals immunized with snake venoms. Their therapeutic success lies in their ability to mitigate the progress ...