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The effect of myotoxins isolated from Bothrops snake venoms on multilamellar liposomes: relationship to phospholipase A2, anticoagulant and myotoxic activities
(1991-12)
The effect of four myotoxins isolated from Bothrops snake venoms on the release of peroxidase trapped in large multilamellar liposomes was studied and correlated to their phospholipase A2, myotoxic and anticoagulant ...
SDS‑induced hexameric oligomerization of myotoxin‑II from Bothrops asper assessed by sedimentation velocity and nuclear magnetic resonance
(2023)
We report the solution behavior, oligomerization state, and structural details of myotoxin-II purified from the venom of
Bothrops asper in the presence and absence of sodium dodecyl sulfate (SDS) and multiple lipids, as ...
Profiling the venom gland transcriptomes of Costa Rican snakes by 454 pyrosequencing
(BMC Genomics, 12:259, 2011, 2011)
Background: A long term research goal of venomics, of applied importance for improving current antivenom
therapy, but also for drug discovery, is to understand the pharmacological potential of venoms. Individually ...
Group-II phospholipase A2 enzymes
(2015-05)
Phospholipase A2 are esterolytic enzymes that catalyze the hydrolysis of 1,2-diacyl-3-sn-glycerophospholipids at the C2 position, resulting in the formation of lysophospholipids and free fatty acid. They constitute one of ...
A lipidomic perspective of the action of group IIA secreted phospholipase A2 on human monocytes: lipid droplet biogenesis and activation of cytosolic phospholipase A2α
(2020)
Phospholipase A2s constitute a wide group of lipid-modifying enzymes which display a variety of functions in innate immune responses. In this work, we utilized mass spectrometry-based lipidomic approaches to investigate ...
An acidic phospholipase A2 with antibacterial activity from Porthidium nasutum snake venom
(2012-04)
Snake venoms are complex mixtures of proteins among which both basic and acidic phospholipases A2
(PLA2s) can be found. Basic PLA2s are usually responsible for major toxic effects induced by snake venoms,
while acidic ...
Proteomic analysis of the mandibular glands from the Chinese crocodile lizard, Shinisaurus crocodilurus – another venomous lizard?
(2023)
Based on its phylogenetic relationship to monitor lizards (Varanidae), Gila monsters (Heloderma spp.), and the earless monitor Lanthanotus borneesis, the Chinese crocodile lizard, Shinisaurus crocodilurus, has been assigned ...
First look into the venom of Roatan Island´s critically endangered coral snake Micrurus ruatanus: proteomic characterization, toxicity, immunorecognition and neutralization by an antivenom
(2019)
A proteomic and toxicological study of the venom from one specimen of Micrurus ruatanus, a critically endangered
coral snake species endemic to Roatan Island, Honduras, was carried out. Immunorecognition and
neutralization ...
Biological and structural characterization of crotoxin and new isoform of crotoxin B PLA2 (F6a) from Crotalus durissus collilineatus snake venom
(2006)
A new crotoxin B isoform PLA2 (F6a), from Crotalus durissus collilineatus was purified from
by one step reverse phase HPLC chromatography using l-Bondapack C-18 column analytic.
The new crotoxin B isoform PLA2 (F6a), ...
MipLAAO, a new L-amino acid oxidase from the redtail coral snake, Micrurus mipartitus
(2018-06-08)
L-amino acid oxidases (LAAOs) are ubiquitous enzymes in nature. Bioactivities
described for these enzymes include apoptosis induction, edema formation, induction
or inhibition of platelet aggregation, as well as antiviral, ...