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N-Formyl-Perosamine Surface Homopolysaccharides Hinder the Recognition of Brucella abortus by Mouse Neutrophils
(2016-06)
Brucella abortus is an intracellular pathogen of monocytes, macrophages, dendritic cells, and placental trophoblasts. This bacterium
causes a chronic disease in bovines and in humans. In these hosts, the bacterium also ...
Índices bibliométricos y revistas de ‘corriente central’: implicaciones para el desarrollo de las ciencias naturales en Costa Rica
(2015)
Dada esta amplia variación en la calidad de
las publicaciones en ciencias naturales, es
esencial para la comunidad científica tener una
perspectiva clara de dicha heterogeneidad y de
sus implicaciones ...
Molecular architecture of the antiophidic protein DM64 and its binding specificity to myotoxin II from Bothrops asper venom
(2022)
DM64 is a toxin-neutralizing serum glycoprotein isolated from Didelphis aurita, an ophiophagous marsupial naturally resistant to snake envenomation. This 64 kDa antitoxin targets myotoxic phospholipases A2, which account ...
Effect of a recombinant Lys49 PLA2 myotoxin and Lys49 PLA2-derived synthetic peptides from Agkistrodon species on membrane permeability to water.
(2004)
The aim of this work was to study the effect of recombinant ACL myotoxin, a Lys49PLA2 from Agkistrodon contortrix
laticinctus snake venom and Lys49PLA2-derived synthetic peptides corresponding to the region 115–129 of ...
Role of enzymatic activity inmuscle damage and cytotoxicity induced by Bothrops asper Asp49 phospholipase A2 myotoxins: are there additional effector mechanisms involved?
(Peer Journal 2:e569; DOI 10.7717/peerj.569, 2014-09-16)
Viperid venoms often contain mixtures of Asp49 and Lys49 PLA2 myotoxin isoforms,
relevant to development of myonecrosis. Given their difference in catalytic
activity, mechanistic studies on each type require highly ...
Neutralization of four Peruvian Bothrops sp. snake venoms by polyvalent antivenoms produced in Perú and Costa Rica: preclinical assessment
(2005-06)
Envenomations after bites inflicted by snakes of the genus Bothrops constitute a public health hazard in Perú, and the intravenous administration of equine-derived antivenoms represents the only scientifically validated ...
Danger in the canopy: comparative proteomics and bioactivities of the venoms of the South American palm viper Bothrops bilineatus subspecies bilineatus and smaragdinus, and antivenomics of B. b. bilineatus (Rondônia) venom against the Brazilian pentabothropic antivenom
(2020)
We report a structural and functional proteomics characterization of venoms of the two subspecies (Bothrops bilineatusbilineatus and B. b. smaragdinus) of the South American palm pit viper from the Brazilian state of ...
Niveles de inmunoglobulinas séricas (IgG, IgA e IgM) en adultos jóvenes sanos, por el método de inmunodifusión radial
(1985)
Se determinó la concentración de IgG, IgA, e IgM en el suero de 49 estudiantes universitarios normales, de 18 a 25 años. Para esto se empleó el método de inmunodifusión radial, en placas comerciales. Los resultados fueron ...
Cellular pathology induced by snake venom phospholipase A2 myotoxins and neurotoxins: common aspects of their mechanisms of action
(2008-06-20)
A large variety of snake toxins evolved from PLA2 digestive enzymes through a process of ‘accelerated evolution’. These toxins have different tissue targets, membrane receptors and mechanisms of alteration of the cell ...
A Lys49 Phospholipase A2, Isolated from Bothrops asper Snake Venom, Induces Lipid Droplet Formation in Macrophages Which Depends on Distinct Signaling Pathways and the C-Terminal Region
(2013)
MT-II, a Lys49PLA2 homologue devoid of catalytic activity from B. asper venom, stimulates inflammatory events in macrophages. We investigated the ability of MT-II to induce formation of lipid droplets (LDs), key elements ...